DNA GYRASE AS A TARGET FOR QUINOLONES

DNA Gyrase as a Target for Quinolones

Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials.DNA gyrase is one of the primary targets of quinolones, broad-spectrum antibacterial agents and are used as pc381ls a first-line drug for various types of infections.H

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Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.

An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV.This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling.Thus, mapale dre

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Whose sample is it anyway? Widespread misannotation of samples in transcriptomics studies [version 1; referees: 2 approved]

Concern about the reproducibility and reliability of biomedical research has been rising.An understudied issue is the prevalence of sample mislabeling, one dea eyewear impact of which would be invalid comparisons.We studied this issue in a corpus of human transcriptomics studies by comparing the provided annotations of sex to the expression levels

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